Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
When we speak, we are able to use what we hear about that speech (auditory feedback) to alter our speech movements both in real time within a single word (feedback control) as well as over longer time scales across multiple utterances (feedforward control).
Disorders of speech production may be accompanied by abnormal processing of speech sensory feedback. Here, we introduce a semi-automated analysis designed to assess the degree to which speakers use natural online feedback to decrease acoustic variability in spoken words.
Adult neural stem cells in mouse models of fragile X syndrome (FXS) have elevated histone acetylation, leading to reduced neurogenesis. Treatment with either Nutlin-3 or Curcumin rebalances histone acetylation and rescues cognitive functions
A single-word identification test was used to study speech production in children and adults with Down syndrome (DS) to determine the developmental pattern of speech intelligibility with an emphasis on vowels.
The current study investigated the relation between postural balance and performance of daily living skills (DLS) in youth with autism spectrum disorder (ASD). Fifty-two youth with ASD (6–17 years; IQ ≥ 67) completed standardized balance testing and parent-reported DLS measures.
Children who cannot effectively read print because of a visual, physical, perceptual, developmental, cognitive or learning disability, are considered to have a print disability.
Our goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and determine its relevance to human white matter disease.
Human induced-pluripotent stem cells are a promising resource for propagation of myogenic progenitors. Our group recently reported a unique protocol for the derivation of myogenic progenitors directly (without genetic modification) from human pluripotent cells using free-floating spherical culture.
This study compared gesture use in young children with DS and TD as well as how mothers respond to child gestures based on child age and diagnosis.
How does social information affect the perception of taste early in life? Does mere knowledge of other people’s food preferences impact children’s own experience when eating? In Experiment 1, 5- and 6- year- old children consumed more of a food described as popular with other children than a food that was described as unpopular with other children, even though the two foods were identical.
