Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Longitudinal changes in cortical thickness in autism and typical development Legend: Abnormal age-related cortical thickness trajectories in ASD. Coloured brain regions identify significant group differences in age-related cortical thickness changes. Each scan is represented by a dot and repeated scans are connected by lines. Regions depicted were significant both before and after controlling for …
Title: Effects of classroom bilingualism on task-shifting, verbal memory, and word learning in children Legend: Children who experienced two years of Spanish exposure in a dual-immersion classroom outperformed monolingual children when learning new made-up words (e.g., “gateke”). This was especially true when they learned new words for objects they were familiar with (e.g., turtle). Citation: …
Title: Increasing Nrf2 activity in astrocytes confers protection to Nrf2 knockout neurons Legend: Nrf2 KO cultures were traduced with 50 MOI adenovirus-Nrf2-GFP or adenovirus-GFP 48 hours prior to H2O2 treatment. Cultures were immunohistochemically analyzed following treatment with 50 µM H2O2. Neuronal marker, beta(III)-tubulin (red), eGFP (green); Hoechst 3258 (blue). Citation: Kraft, A.D., Johnson, D.A. and J.A. Johnson (2004). Nrf2-dependent ARE …
Title: Perceptual Ratio Processing Predicts Fractions Skills Legend: (Lay): College students were asked to decide which of two ratios were larger (examples in a-d) that were presented for 1.5 seconds. We show that people who were better at this perceptual task also performed better on four tasks involving symbolic fractions: comparing symbolic fractions (e.g., saying …
Title: iPSC derived Optic Vesicles (OVs)/Neural Retinal Progenitors (NRPs) – Production, Characterization and Cryopreservation Legend: 1) Representative pictures of selected OVs derived from iPSCs grown on E8/Matrigel. iPSCs, cultured on E8/Matrigel, mTeSR1/Matrigel, and E8/vitronectin, were differentiated into OVs (Optic vesicle-like structures) composed of NRPCs (neuroretinal progenitor cells). 2) Characterization of OVs (60 days in culture)- …
Title: Support Needs of Fathers and Mothers of Children and Adolescents with Autism Spectrum Disorder Legend: Left, top image: The most support needs most frequently rated as both important and unmet for both mothers and fathers. Mothers’ non-overlapping top important, unmet support needs were child-focused (financial support for treatments, information about programs and services, and …
Title: Characterization of a unique cell population marked by transgene expression in the adult cochlea of nestin-CreER(T2)/tdTomato-reporter mice Legend: Left image: Cochlea from an adult nestin-CreERT2/tdTomato-reporter mouse 56 days post tamoxifen injection. Low power macroscopic imaging analysis showed a pattern of tdTomato expression on the neural aspect of Sox2-positive supporting cells. An apical-basal gradient was not …
Legend: Top: A-B. 3D rendering of structured illumination microscopy (SIM) images of a human forebrain neuron growth cone triple-labeled for F-actin (red), ßIII tubulin (blue) and ADAM17 (green). A view of the apical surface (A) shows an F-actin foci in the central domain (arrowhead), which is revealed to be an apically directed protrusion in a lateral …
Legend: Left image: Children chronically at-risk for sensory processing disorders are more likely to have lower birthweight, lower gestational age, less sootheable and more fearful temperaments as toddlers. Right image: Severity of Age 4 sensory related behaviors (tactile sensitivity, auditory sensitivity, and movement) vary by risk for sensory processing disorders assessed at ages 2 and 7 …
Title: Pharmacological modulation of photoreceptor outer segment degradation in Best disease patient-derived hiPSC-RPE Legend: (a) Representative western blot analysis comparing the amount of the POS protein RHO in untreated and VPA-treated (500 µmol/l) BD hiPSC-RPE at 0 and 24 hours after POS feeding. (b) Quantification of RHO levels 24 hours after POS feeding in untreated versus …
