Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Twenty years ago, a seminal discovery by researchers at UW–Madison introduced stem cells to the world. Since then, this new tool has transformed science and opened new doors for translational research. Stem cells are undifferentiated “master cells” capable of transforming into any of the body’s cell types. Waisman Center researchers have been at the forefront …
From five examples of human embryonic stem cells in 1998 to 1,364 different lines of stem cell cultures today, the field of stem cell research has come so far in the past 20 years. The Capital Times highlights stem cell research milestones, challenges and future prospects on the 20th anniversary of stem cell research at …
The ability to understand emotional experiences of others, empathy, is a valuable skill for effective social interactions. Various types of training increase empathy in adolescents, but their impact on brain circuits underlying empathy has not been examined. Video games provide a unique medium familiar and engaging to adolescents and can be used to deliver training at scale.
To mark the 20th anniversary of the stem cell discovery at UW–Madison, the Wisconsin State Journal featured a series of stories on stem cell research, highlighting the work of Waisman Center investigators David Gamm, Anita Bhattacharyya, Su-Chun Zhang, affiliate Randall Ashton, as well as Waisman Biomanufacturing. Researchers at the Waisman Center use stem cells— undifferentiated …
Transplantation of human pluripotent stem cell (hPSC)-derived neurons into chick embryos is an established preliminary assay to evaluate engraftment potential. Yet, with recent advances in deriving diverse human neuronal subtypes, optimizing and standardizing such transplantation methodology for specific subtypes at their correlated anatomical sites is still required.
A story in the Milwaukee Journal Sentinel reflects on the history of stem cells and its future direction. Two decades after the first stem cell breakthrough, the promising biological discovery is beginning to take steps toward clinical trials. Waisman Center investigator David Gamm, who researches stem cell therapies for diseases of the eye, reflects on …
Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.
Waisman Center social workers Paola Perez and Erin Thomson were featured guests on the Larry Meiller Show on Wisconsin Public Radio’s the Ideas Network. Perez and Thomson discussed a broad range of autism-related topics including diagnosis, treatment services, and support for families. The show aired on October, 25, 2018. Listen to the full broadcast here.
In a study published today, Waisman Center investigators Su-Chun Zhang, Albee Messing and colleagues point to new understandings of the broad range of effects that result from the GFAP mutation impacting astrocytes — important supporting cells which comprise 20 to 40 percent of all cells in the brain. Cells donated by patients with Alexander disease …
Astrocytes play an important role in Rett syndrome (RTT) disease progression. Although the non-cell-autonomous effect of RTT astrocytes on neurons was documented, cell-autonomous phenotypes and mechanisms within RTT astrocytes are not well understood. We report that spontaneous calcium activity is abnormal in RTT astrocytes in vitro, in situ, and in vivo.
