Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [11C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [18F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.
Alzheimer’s disease
New study shows nuanced and complex relationship between tau and brain cell loss in Alzheimer’s Disease
At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau …
Barbara B. Bendlin, PhD – Slide of the Week
The gut microbiome is a potentially modifiable risk factor for Alzheimer’s disease (AD); however, understanding of its composition and function regarding AD pathology is limited.
Sigan Hartley, PhD – Slide of the Week
Mean physical and behavioral depressive symptoms on the Reiss Screen of Maladaptive Behavior (RSMB) across four data collection cycles in sample of 262 adults with Down syndrome. Blue line is for those with low PET amyloid and green line for those with elevated PET amyloid.
Tracy L. Hagemann, PhD – Slide of the Week
Title: Congruent gene expression in Alexander disease model mice and human Alzheimer’s disease Legend: (A) A Rank-Rank Hypergeometric Overlap (RRHO) heatmap comparing a composite gene expression portrait of human Alzheimer’s disease (AD, X axis) with …
Daifeng Wang, PhD – Slide of the Week
Genotypes are strongly associated with disease phenotypes, particularly in brain disorders. However, the molecular and cellular mechanisms behind this association remain elusive.
UW-Madison researchers first to 3D-print functional human brain tissue
A team of University of Wisconsin–Madison scientists has developed the first 3D-printed brain tissue that can grow and function like typical brain tissue.
Neurodegeneration research at the Waisman Center from gene to organelle to cell to brain
Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease, and retinitis pigmentosa all have different manifestations and affect different body functions, but they are all connected by one mechanism: neurodegeneration.
Scientists produce human norepinephrine neurons from stem cells, with significant implications for researching diseases like Alzheimer’s and Parkinson’s
Researchers a have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer’s and Parkinson’s diseases and used the discovery to grow the neurons from stem cells for the first time.
Understanding the connection between Down syndrome and Alzheimer’s disease
Allison and Amber Westemeier get excited every time they take a trip to the Waisman Center from Oshkosh, WI.