Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.
Alzheimer’s disease
Studying Alzheimer’s disease in individuals with Down syndrome
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her …
Barbara B. Bendlin, PhD – Slide of the Week
To test the hypothesis that cognitively unimpaired individuals with Alzheimer disease (AD) neuropathology differ from individuals with AD dementia on biomarkers of neurodegeneration, synaptic dysfunction, and glial activation.
Luigi Puglielli, MD, PhD – Slide of the Week
The aberrant accumulation of toxic protein aggregates is a key feature of many neurodegenerative diseases, including Huntington’s disease, amyotrophic lateral sclerosis and Alzheimer’s disease. As such, improving normal proteostatic mechanisms is an active target for biomedical research.
Bradley T Christian, PhD
Alzheimer’s disease is characterized by accumulation of beta amyloid (Aβ) and hyperphosphorylated tau proteins, which neuropathology suggests follow distinct spatiotemporal patterns.
Barbara Bendlin, PhD
Myelin and myelin-producing oligodendrocytes appear to be affected in Alzheimer’s disease (AD), but this is understudied in humans, particularly in the early stages of disease development.
The chatter within our cells
Waisman Center investigator Luigi Puglielli had trouble with only one class in medical school: biochemistry. Yet today he uses biochemical approaches to study some of the vital molecular mechanisms that regulate brain physiology and pathology …
Thoughts of Gratitude: Dan Campbell
Dan Campbell passed away recently. He was a prolific artist and contributed many pieces of his work to the Waisman Center’s Harvey A. Stevens Collection of Art by People with Disabilities. Dan and his family …
UW researchers find possible treatment for Alzheimer’s
January 19, 2016 Channel 3000 University of Wisconsin researchers say they’ve found a treatment to clean up the plaques that form in the brain of mice with Alzheimer’s disease. The research published in the journal …
Waisman Center partners on new multi-site NIH initiative to find Alzheimer’s biomarkers in Down syndrome
Brad Christian, PhD, Waisman investigator and associate professor of medical physics and psychiatry, is part of a new National Institutes of Health initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome.