A new machine learning algorithm developed at UW-Madison is helping researchers untangle a complex puzzle: the molecular mechanisms behind developmental disabilities and neurodegenerative diseases. COSIME, created by the lab of Waisman investigator Daifeng Wang, PhD, associate professor of biostatistics and medical informatics, and computer sciences, offers a powerful new way to integrate and interpret multiple types of biological data which can give scientists a clearer view of how different cellular clues come together to shape disease outcomes.
Alzheimer’s Disease
New study shows nuanced and complex relationship between tau and brain cell loss in Alzheimer’s Disease
At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau …
A family’s commitment to Down syndrome research at the Waisman Center spans four decades and counting
When Heather Huismann was in middle school she called the police on her teacher. “He was not teaching me very well,” Heather says.
UW-Madison’s Cool Science Image Contest: Waisman winners
Matt Zammit, PhD, Waisman scientist in the Brain Imaging Core, and affiliate investigator Erik Dent, PhD, are both winners of UW-Madison’s Cool Science Image Contest.
UW-Madison researchers first to 3D-print functional human brain tissue
A team of University of Wisconsin–Madison scientists has developed the first 3D-printed brain tissue that can grow and function like typical brain tissue.
Fit Families makes exercise accessible to children with disabilities
Families and their children with intellectual and developmental disabilities often face many barriers to getting accessibility to exercise.
Neurodegeneration research at the Waisman Center from gene to organelle to cell to brain
Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), Charcot-Marie-Tooth disease, and retinitis pigmentosa all have different manifestations and affect different body functions, but they are all connected by one mechanism: neurodegeneration.
Scientists produce human norepinephrine neurons from stem cells, with significant implications for researching diseases like Alzheimer’s and Parkinson’s
Researchers a have identified a protein key to the development of a type of brain cell believed to play a role in disorders like Alzheimer’s and Parkinson’s diseases and used the discovery to grow the neurons from stem cells for the first time.
Understanding the connection between Down syndrome and Alzheimer’s disease
Allison and Amber Westemeier get excited every time they take a trip to the Waisman Center from Oshkosh, WI.
Weight loss may be early predictor of Alzheimer’s disease in Down syndrome
Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent.