Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Could Alzheimer’s disease and schizophrenia be biologically connected?
A new study from the lab of UW-Madison professor of medicine Luigi Puglielli, MD, PhD, opens a door to potential treatments for diseases of age, such as Alzheimer’s disease, by defining the roles of two enzymes that are imperative to protein production.
A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for developing Alzheimer’s disease beginning in their late 40s, because of their unique biology. The vast majority will eventually develop the …
Research has shown voluntary running is an activity most commonly associated with the reversal of negative impacts of aging and neurodegeneration, but little is understood about why that is.
New research by University of Wisconsin–Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.
A gift from the Mancheski Foundation continues to provide integral support to doctoral student Matthew Zammit as he furthers his research on the progression of Alzheimer’s disease in individuals with Down syndrome. Zammit is beginning his fourth year as a doctoral student working in the laboratory of Bradley Christian, PhD, a Waisman investigator and professor …
Not so many years ago, people with Down syndrome rarely survived to middle age. Many died young due to heart problems associated with the congenital condition. Today, advances in treatment have allowed them to live longer, healthier lives.
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her home in central Illinois to the University of Wisconsin–Madison Waisman Center to “embark on an afternoon of adventure.” At the …
Individuals undergoing a magnetic resonance imaging (MRI) scan often need to minimize movements for up to 10 minutes at a time to maximize scan quality. That can be challenging for many people.
In a study published in Aging Cell, researchers at the University of Wisconsin–Madison show that mice making too much of a human protein called AT-1 show signs of early aging and premature death, which are also symptoms of the human disorder progeria. Researchers were able to reverse the signs of accelerated aging and early death …
