Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.
Four Waisman Center investigators will dig deeper into the function of genes implicated in autism and brain development with support from the prestigious Simons Foundation 2022 Pilot Award.
Title: Single-cell gene expression analysis reveals signatures of adult neurogenesis in mouse, pig and macaque, but not in humans. Legend: A) Schematic of the analytic workflow. DG: dentate gyrus; CA: cornu ammonis; Sub: subiculum; EC: entorhinal cortex B) Seurat integration of all cells in the dentate gyrus (each dot represents one cell). RGL: radial glia-like cell; …
Waisman Center researchers are creating a new approach to study how changes to brain development in the womb result in intellectual disability in people with Down syndrome.
Sousa is the second hire in the cluster initiative that includes a biostatistician, a neuroscientist, and a geneticist.
Human nervous system development is an intricate and protracted process that requires precise spatiotemporal transcriptional regulation. We generated tissue-level and single-cell transcriptomic data from up to 16 brain regions covering prenatal and postnatal rhesus macaque development.
