Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
Title: Associations of prenatal maternal depression and anxiety symptoms with infant white matter microstructure Legend: Decreased frontal neurite density in the prefrontal white matter (blue highlighted regions) of 1-month old infants was associated with higher prenatal maternal depression and anxiety. Advanced diffusion MRI brain scans were performed on 101 infants at the Waisman Center for this …
Individuals undergoing a magnetic resonance imaging (MRI) scan often need to minimize movements for up to 10 minutes at a time to maximize scan quality. That can be challenging for many people.
Mapping White Matter Microstructure in the One Month Human Brain Legend: Matched coronal and axial slices through the of the population averaged diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) parameters (Left). Gestation corrected age relationships of fractional anisotropy (FA), radial diffusivity (RD) and neurite density (νIC) for left hemisphere white …
Title: Investigating the Microstructural Correlation of White Matter in Autism Spectrum Disorder Legend: Graphical visualization (‘connectogram’) of brain white matter networks of the examined typically developing (TD) and autism spectrum disorder (ASD) groups. Individual white matter tracts were broadly grouped by region (outside labels), while the individual tract is indicated by the inside of the …
Several research and infrastructure projects featuring Waisman Center researchers as the primary or co-investigator have been selected for the second round of funding through the UW2020
Brad Christian, PhD, Waisman investigator and associate professor of medical physics and psychiatry, is part of a new National Institutes of Health initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome.
A new study by Waisman Center investigators Andy Alexander, PhD, professor of medical physics and psychiatry, Janet Lainhart, MD, professor of psychiatry and Brittany Travers, PhD, assistant professor of kinesiology, indicates a nerve bundle at the base of the brain is structurally compromised in people with autism. The study was recently featured by the Simons Foundation Autism Research Initiative.
Title: Multiple contrast MRI with retrospective motion correction Legend: Representative example of multiple image contrasts from a new brain imaging technique MPnRAGE developed in the Alexander Lab in the Waisman Brain Imaging Core. The MPnRAGE method can generate multiple inversion recovery contrasts, quantitative T1 relaxometry, and tissue specific (gray matter or white matter) maps. Whole …
