A gift from the Mancheski Foundation continues to provide integral support to doctoral student Matthew Zammit as he furthers his research on the progression of Alzheimer’s disease in individuals with Down syndrome. Zammit is beginning …
Bradley Christian
Bradley T Christian, PhD – Slide of the Week
Individuals with Down syndrome (DS) are at increased risk of developing Alzheimer’s disease (AD) and show the earliest signs of amyloid-β (Aβ) deposition in the striatum. The metric for tracking Aβ burden using PET radiotracers frequently uses average standard uptake value ratios (SUVr) in signature regions of the brain specific to Aβ deposition.
Bradley Christian, PhD – Slide of the Week
Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.
Studying Alzheimer’s disease in individuals with Down syndrome
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her …
Bradley T Christian, PhD
Alzheimer’s disease is characterized by accumulation of beta amyloid (Aβ) and hyperphosphorylated tau proteins, which neuropathology suggests follow distinct spatiotemporal patterns.
Waisman researchers part of several UW2020 awards
Several research and infrastructure projects featuring Waisman Center researchers as the primary or co-investigator have been selected for the second round of funding through the UW2020
Waisman Center partners on new multi-site NIH initiative to find Alzheimer’s biomarkers in Down syndrome
Brad Christian, PhD, Waisman investigator and associate professor of medical physics and psychiatry, is part of a new National Institutes of Health initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome.
Bradley T. Christian, PhD
Legend: Left panel: General patterns of [11C]PiB binding in participants with Down syndrome (DS). PiB binds to amyloid-β plaques, a neuropathological hallmark of Alzheimer’s disease (AD). The top row shows nonspecific white matter binding. The …
Down syndrome helps researchers understand Alzheimer’s disease
The link between a protein typically associated with Alzheimer’s disease and its impact on memory and cognition may not be as clear as once thought, according to a new study from the University of Wisconsin-Madison’s …