After more than a decade of work, researchers at the University of Wisconsin–Madison’s Waisman Center reported promising results in the lab and in animal models that could set the stage for developing a treatment for Alexander disease, a rare and usually fatal neurological disease with no known cure.
Year: 2017
Peter Ferrazzano, MD
Immunostaining and microglia isolation via magnetic cell sorting was performed at postnatal day 2, 9, 30 and 60 (P2, P9, P30, P60). Microglia branching and soma size were quantified using semiautomated software analysis (Imaris, Oxford Insturments).
2017 year in review
We’re delighted to share a video highlighting many of the strides we have made over the past year. Your generous and thoughtful contributions help us continue to pioneer research and expand clinical services that benefit …
Randolph Ashton, PhD
Human pluripotent stem cell-derived neural organoids provide unprecedented potential to recapitulate human brain and spinal cord tissues in vitro. However, organoid morphogenesis relies upon cell-intrinsic self-assembly of biomimetic tissue structures in the absence of normal developmental constraints and morphogen signaling centers.
After decades of service, Waisman clinician Tina Iyama-Kurtycz retires in December
Iyama-Kurtycz’s journey from an 8-year-old with a dream to a skilled clinician took her to medical school at the University of Michigan and a residency at the University of Kansas. “While at Kansas, I met a pediatrician who was taking care of children with disabilities and I realized that’s what I wanted to do,” says Iyama-Kurtycz.
Waisman Center director search advances as interim leadership is named
“Dr. Messing has been an outstanding director of this center since his appointment in 2015. He is both a superb scientist and has been a strong leader across this center’s multifaceted mission,” says Norman Drinkwater, UW–Madison associate vice chancellor for research in biological sciences.
Childhood stress and life risks
Adults who lived high-stress childhoods have trouble reading the signs that a loss or punishment is looming, leaving themselves in situations that risk avoidable health and financial problems and legal trouble.
Maureen S. Durkin, PhD, DrPH – Slide of the Week
Objectives: To describe the association between indicators of SES and the prevalence of ASD in the United States during the period 2002 to 2010, when overall ASD prevalence among children more than doubled, and to determine whether SES disparities account for ongoing racial and ethnic disparities in ASD prevalence.
Susan Ellis Weismer, PhD
Weak central coherence (processing details over gist), poor oral language abilities, poor suppression, semantic interference, and poor comprehension monitoring have all been implicated to affect reading comprehension in individuals with ASD.
Video game improves balance in youth with autism
“We think this video game-based training could be a unique way to help individuals with ASD who have challenges with their balance address these issues,” says Travers, an investigator at UW–Madison’s Waisman Center and an assistant professor of kinesiology.