Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
May is #ALSAwarenessMonth and Waisman investigator Su-Chun Zhang, MD, PhD, uses stem cells to uncover the cause of ALS with the hope of developing treatments and therapies.
Twenty years ago, a seminal discovery by researchers at UW–Madison introduced stem cells to the world. Since then, this new tool has transformed science and opened new doors for translational research. Stem cells are undifferentiated “master cells” capable of transforming into any of the body’s cell types. Waisman Center researchers have been at the forefront …
In a study published today, Waisman Center investigators Su-Chun Zhang, Albee Messing and colleagues point to new understandings of the broad range of effects that result from the GFAP mutation impacting astrocytes — important supporting cells which comprise 20 to 40 percent of all cells in the brain. Cells donated by patients with Alexander disease …
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her home in central Illinois to the University of Wisconsin–Madison Waisman Center to “embark on an afternoon of adventure.” At the …
Picture a crisp October morning in Madison, Wisconsin – the bright colors of fall leaves, mists over the blue waters of Lake Mendota and – on one Sunday (the 14th this year) – a crowd of excited people waiting to run, walk or roll in the 2018 Waisman Whirl for ALL Abilities!
Research by Waisman affiliate Jon Audhya shows new insight into the molecular basis underlying the neurodegenerative condition, hereditary spastic paraplegia (HPS). His recent study shows how a mutation in the TFG gene–one of several linked to HPS–impairs neurons from forming structures needed to transmit signals properly. Read the full article, please visit https://www.med.wisc.edu/news-and-events/2018/september/nerve-cell-protein-factory/
In a study published in Aging Cell, researchers at the University of Wisconsin–Madison show that mice making too much of a human protein called AT-1 show signs of early aging and premature death, which are also symptoms of the human disorder progeria. Researchers were able to reverse the signs of accelerated aging and early death …
After more than a decade of work, researchers at the University of Wisconsin–Madison’s Waisman Center reported promising results in the lab and in animal models that could set the stage for developing a treatment for Alexander disease, a rare and usually fatal neurological disease with no known cure.
Waisman Center investigator Luigi Puglielli had trouble with only one class in medical school: biochemistry. Yet today he uses biochemical approaches to study some of the vital molecular mechanisms that regulate brain physiology and pathology across the lifespan. Puglielli, who is a professor in the Department of Medicine, focuses on trying to understand how proteins …
How much information can we extract from a five-minute recording of someone talking? Enough to tell whether that individual may be genetically predisposed to some health complications, according to researchers at the University of Wisconsin–Madison’s Waisman Center and Wisconsin Institute for Discovery. In a new study published this month in Scientific Reports, the researchers used …
