We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSPNMDA) or long-term potentiation (LTP) in vitro at concentrations that block contextual conditioning in vivo. Here we tested one possible explanation for the mismatch – that the hippocampus is relatively resistant to CPP compared to other brain structures engaged in contextual fear conditioning.
The sound of the Waisman Center’s work to improve cochlear implants
The Waisman Center has been at the forefront of research on cochlear implants and hearing science for more than two decades.
WIN for the win: Wellness Inclusion Nursing helps improve quality of life of individuals with disabilities through nursing consulting
WIN is a Waisman Center Community Outreach Wisconsin (COW) program with nurses that serve as consultants for individuals with intellectual and developmental disabilities (IDD) and their families, caregivers, residential and vocational team members, and health care providers.
Ben Parrell, PhD – Slide of the Week
Sensory errors induce two types of behavioral changes: rapid compensation within a movement and longer-term adaptation of subsequent movements.
Waisman Center welcomes new investigator with a focus on early language intervention work
Alper’s path to communication sciences was not straight forward. She initially started down the biotechnology path and sprinkled in some reproductive embryology research as well. It wasn’t until she started in a voice physiology lab seeking research with more direct human interaction that she found the path she wanted to be on.
Weight loss may be early predictor of Alzheimer’s disease in Down syndrome
Unintentional weight loss in people with Down syndrome may predict the onset of Alzheimer’s disease long before typical cognitive symptoms like memory loss and dementia are apparent.
Kennedy’s other moon shot: The origins of intellectual and developmental disabilities research centers and the Waisman Center
When President Kennedy made his inaugural speech in 1961, there was no mention of initiatives on intellectual and developmental disabilities (IDDs). Yet, the efforts by his administration and the Kennedy family to improve the lives of individuals with disabilities and their families are one of their most enduring legacies. The Waisman Center, University of Wisconsin-Madison bears the indelible fingerprints of those efforts.
Carrie Niziolek, PhD – Slide of the Week
Although movement variability is often attributed to unwanted noise in the motor system, recent work has demonstrated that variability may be actively controlled.
Waisman postdoctoral training program: Training the next generation of IDD researchers
The first two years of the grant provided funding for two seminars in an academic year, but in a short span, seeing the tangible benefits these had, they expanded from two lectures a year, to two a month.
Waisman investigators receive grant to improve brain imaging in young children
A team of investigators at the Waisman Center was recently awarded a $2.5 million grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health to both improve brain imaging techniques for infants and build a quantitative atlas of typical early brain development.