Max McLachlan (Christian Lab) Slide of the Week

Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [11C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [18F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.

New study shows nuanced and complex relationship between tau and brain cell loss in Alzheimer’s Disease

At a Glance Loss of synapses, the connections between neurons that allow them to communicate, is a primary driver of cognitive decline in Alzheimer’s disease. Researchers expected a strong connection between synapse loss and tau …

Alzheimer’s Biomarkers Consortium – Down Syndrome: ABC-DS (Christian & Hartley)

The National Institutes of Health-funded Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a large multi-center research initiative to find biomarkers to track Alzheimer’s disease in Down syndrome. The Waisman Center is part of this multi-site …

Thoughts of gratitude: The Dewey family is a catalyst of support for the Waisman Center

Individuals with Down syndrome are at higher risk of developing Alzheimer’s disease, and it typically presents it at an earlier age than the general population. It is estimated that 90% of people with Down syndrome will have developed Alzheimer’s by age 65.