Advancing knowledge of human development, developmental disabilities, and neurodegenerative diseases.
The National Institutes of Health-funded Alzheimer’s Biomarkers Consortium – Down Syndrome (ABC-DS), a large multi-center research initiative to find biomarkers to track Alzheimer’s disease in Down syndrome. The Waisman Center is part of this multi-site study across the United States and at University of Cambridge in England. As part of the study, the Waisman Center …
Structural pathologies, such as brain, are present at birth in Down syndrome (trisomy 21), reflecting embryonic origins that are generally associated with smaller organs or reduced growth.
Be included! Families of children with Down syndrome are invited to participate in our new study about genetics and health. The Waisman BioLibrary is recruiting youth with Down syndrome ages 0 – 17 years. Families make a one-time visit to the Waisman Center at UW–Madison or a remote visit option is available. The visit lasts …
PET amyloid [11C]PiB imaging has revealed early detection of Aβ in the striatum in individuals with Down Syndrome (DS), a group carrying genetic risk for AD.
Boxplots depicting median and variation for episodic memory score by PET amyloid beta (Aβ–vs. Aβ+) and tau (TLvs. TH) status in Braakregions I to VI.
By Emily Leclerc, Waisman Science Writer The month of October is Down Syndrome Awareness Month and is dedicated to not only raising awareness about Down syndrome but also to celebrating the abilities and accomplishments of those with Down syndrome. While people with Down syndrome often live long and fruitful lives, the condition does come with …
Waisman Center researchers are creating a new approach to study how changes to brain development in the womb result in intellectual disability in people with Down syndrome.
Down syndrome (DS, trisomy 21) is characterized by intellectual impairment at birth and Alzheimer's disease (AD) pathology in middle age. As individuals with DS age, their cognitive functions decline as they develop AD pathology.
Title: Auditory-Perceptual Features of Speech in Children and Adults with Down syndrome: A Speech Profile Analysis Legend: Table 6 – Principal component loading matrix, first four principal components, vowel features. Note. The largest loadings (in absolute magnitude) on each component define importance. Component loadings greater than .4 in absolute magnitude are shown in bold. Table …
There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer's disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at-risk population. The objective of the study was to longitudinally track performance on cognitive measures in relation to neocortical and striatal amyloid beta (Aβ) in non-demented Down syndrome.
