New research reinforces the link between a cellular quality control system and rare forms of autism

Just like a car factory relies on inspectors to ensure that every vehicle is built correctly, cells depend on internal quality control systems to keep proteins functioning as they should. New research from Waisman Center investigator Luigi Puglielli, MD, PhD, professor of medicine at the University of Wisconsin-Madison, reveals that disruptions in one such system—the endoplasmic reticulum’s acetylation pathway—can lead to rare forms of autism and progeria, offering fresh insights into the cellular roots of these complex conditions.

Health trajectory of mothers of children with developmental disabilities shows a ‘wear-and-tear’ effect starting around age 65

Mothers of children with developmental disabilities experience long-term stress, adapting for many years but showing signs of ‘wear-and-tear’ starting around age 65, affecting their physical and mental health.

Genetic blueprint behind early brain development uncovered by team of Waisman investigators

Early neuronal maturation is not well understood. A new study at Waisman was able to map the gene and regulatory networks driving early neuronal maturation for the first time.