Trisomy 21 (Down syndrome; DS) leads to an overproduction of amyloid precursor protein and an increased risk for early Alzheimer’s disease. A study of the natural history of AD-related neuropathology is ongoing to gain an understanding of the distribution and time course of b-amyloid and tau burden in the brains of adults with DS.
Down syndrome
Studying Alzheimer’s disease in individuals with Down syndrome
About once every year and a half, Erin Harvey takes time off of her job as a teacher’s aide and along with her mom, Nancy, makes a two and a half hour drive from her …
Anita Bhattacharyya, PhD – Slide of the Week
Neuropathology of the Down syndrome cerebral cortex includes fewer interneurons in upper cortical layers.
Houri K. Vorperian, PhD – Slide of the Week
A single-word identification test was used to study speech production in children and adults with Down syndrome (DS) to determine the developmental pattern of speech intelligibility with an emphasis on vowels.
Audra Sterling, PhD – Slide of the Week
This study compared gesture use in young children with DS and TD as well as how mothers respond to child gestures based on child age and diagnosis.
Down Syndrome Clinic helps Jackie Cleveland keep dancing
Brown eyes afire and colorful skirt awhirl, Jackie Cleveland has been dancing since she could walk.
Now in sixth-grade, Jackie, who has Down syndrome, performs at Native American pow wows across the country, dancing traditional Ho-Chunk dances with style and unabashed joy.
A bone to speak and to swallow
Only one out of the more than 200 bones in our bodies is free-floating, with no local attachment to other bones, but it’s no freeloader. The hyoid bone is located in the front of the neck, just below the lower jaw, carrying the weight of the tongue and playing a vital role in speech and swallowing.
Thoughts of Gratitude: Dan Campbell
Dan Campbell passed away recently. He was a prolific artist and contributed many pieces of his work to the Waisman Center’s Harvey A. Stevens Collection of Art by People with Disabilities. Dan and his family …
Holiday Generosity from St. Peter’s School, Reedsburg
Led by their student council members and teachers, the students carried out a ‘Dimes for Down’ syndrome fundraiser and raised more than $700 in support of the Down Syndrome Clinic at the Waisman Center.
Waisman Center partners on new multi-site NIH initiative to find Alzheimer’s biomarkers in Down syndrome
Brad Christian, PhD, Waisman investigator and associate professor of medical physics and psychiatry, is part of a new National Institutes of Health initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome.