People with Down Syndrome (DS) are at high risk for Alzheimer’s disease (AD) because of their unique biology and provide an unparalleled opportunity to develop biomarkers of preclinical AD.
Sigan Hartley
Postdoctoral program equips a new generation of scientists in IDD research
For more than 26 years, the center’s Postdoctoral Training Program in Intellectual and Developmental Disabilities Research has helped shape the careers and research paths of 53 postdoctoral researchers through multidisciplinary training in social, epidemiological, behavioral and biobehavioral research on intellectual and developmental disabilities (IDD).
Sigan Hartley, PhD – Slide of the Week
Boxplots depicting median and variation for episodic memory score by PET amyloid beta (Aβ–vs. Aβ+) and tau (TLvs. TH) status in Braakregions I to VI.
Studying the connection between Alzheimer’s and Down syndrome for Down syndrome awareness month
By Emily Leclerc, Waisman Science Writer The month of October is Down Syndrome Awareness Month and is dedicated to not only raising awareness about Down syndrome but also to celebrating the abilities and accomplishments of …
Sigan Hartley, PhD – Slide of the Week
There is a critical need to identify measures of cognitive functioning sensitive to early Alzheimer’s disease (AD) pathophysiology in Down syndrome to advance clinical trial research in this at-risk population. The objective of the study was to longitudinally track performance on cognitive measures in relation to neocortical and striatal amyloid beta (Aβ) in non-demented Down syndrome.
New NIH-funded initiative will examine Alzheimer’s disease in people with Down syndrome
A team of researchers at the University of Wisconsin–Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome. Adults with Down syndrome are at high risk for …
Sigan Hartley, PhD – Slide of the Week
Family research in the field of ASD has focused on describing the impact of child challenges on parents, usually mothers, and given little attention to the ways in which mothers and fathers reciprocally influence the development of the child with ASD.
Lauren Bishop, PhD – Slide of the Week
We have seen a profound increase in lifespan for individuals with Down syndrome (DS) in the past few decades leading to a large and somewhat understudied population of middle- and older aged adults with DS. One health condition consistently seen in clinic-based DS samples is dementia (including Alzheimer’s disease).
In Wisconsin, 3 in 5 people with Down syndrome diagnosed with dementia by age 55
Not so many years ago, people with Down syndrome rarely survived to middle age. Many died young due to heart problems associated with the congenital condition.
Today, advances in treatment have allowed them to live longer, healthier lives.
Sigan Hartley honored with Romnes Faculty Fellowship
Waisman Center investigator Sigan Hartley, PhD, has been honored with a Romnes Faculty Fellowship. Romnes awards recognize exceptional faculty members who have earned tenure within the last six years. The awards are supported by the …